ALL PUBLICATIONS

2025

X. Zhang, H.W. Chan, Z. Shao, Q. Wang, S. Chow, S.F. Chow*. “Navigating translational research in nanomedicine: A strategic guide to formulation and manufacturing”, Int. J. Pharm. (2025), 671, 125202.
S. Li, B. Xuan, S.N. Wong, H.W. Lee, K.H. Low*, S.F. Chow*. “Towards the discovery of unrevealed flufenamic acid cocrystals via structural resemblance for enhanced topical drug delivery”, Int. J. Pharm. (2025), 668, 124959.

2024

X. Zhang, G. Su, Z. Shao, H.W. Chan, S. Li, S. Chow, C.K. Tsang, S.F. Chow*. “Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke”, Drug Deliv. Transl. Res. (2024). https://doi.org/10.1007/s13346-024-01721-8.
S.N. Wong, M. Fu, S. Li, W.T.C. Kwok, S. Chow, K.H. Low, S.F. Chow*. “Discovery of new cocrystals beyond serendipity: Lessons learned from successes and failures”, CrystEngComm (2024), 26, 1505-1526. (An invited review)
Z. Shao, K.K.G. Tam, V.P.K. Achalla, E.C.Y. Woon, A.J. Mason, S.F. Chow, W.C. Yam, J.K.W. Lam. “Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis”, Int. J. Pharm. (2024), 654, 123960.
S.N. Wong, S. Li, K.H. Low, H.W. Chan, X. Zhang, S. Chow, B. Hui, P.C.Y. Chow, S.F. Chow*. “Development of favipiravir dry powders for intranasal delivery: An integrated cocrystal and particle engineering approach via spray freeze drying”, Int. J. Pharm. (2024), 653, 123896.
H.W. Chan, X. Zhang, S. Chow, D.C.L. Lam, S.F. Chow*. “Inhalable paclitaxel nanoagglomerate dry powders for lung cancer chemotherapy: Design of experiments-guided development, characterization and in vitro evaluation”, Int. J. Pharm. (2024), 653, 123877.
P. Zeng, P. Zhang, H.W. Chan, S.F. Chow, J.K.W. Lam, M. Ip, S.S.Y. Leung. “Storage stability of lusostaphin solution and its pulmonary delivery” Drug Deliv. Transl. Res. (2024). https://doi.org/10.1007/s13346-024-01518-9.

2023

H.W. Chan, H.W. Lee, S. Chow, D.C.L. Lam, S.F. Chow*. “Integrated continuous manufacturing of inhalable remdesivir nanoagglomerate dry powders: design, optimization and therapeutic potential for respiratory viral infections”, Int. J. Pharm. (2023), 644, 123303.
S.N. Wong, K.H. Low, Y.L. Poon, X. Zhang, H.W. Chan, S.F. Chow*. “Synthesis of the first remdesivir cocrystal: design, characterization, and therapeutic potential for pulmonary delivery”, Int. J. Pharm. (2023), 640, 122983.
H.W. Chan, S. Chow, X. Zhang, P.C.L. Kwok, S.F. Chow*. “Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research”, AAPS PharmSciTech (2023), 24 (4), 98. (An invited review)
H.W. Chan, S. Chow, X. Zhang, Y. Zhao, H.H.Y. Tong, S.F. Chow*. “Role of particle size in translational research of nanomedicines for successful drug delivery: discrepancies and inadequacies”, J. Pharm. Sci. (2023), 112 (9), 2371-2384. (An invited review)
Z. Shao, M.Y.T. Chow, S.F. Chow*, J.K.W. Lam. “Co-delivery of D-LAK antimicrobial peptide and capreomycin as inhaled powder formulation to combat drug-resistant tuberculosis”, Pharmaceutical Research (2023), 40, 1073-1086

2022

J. Weng, Z. Shao, H.W. Chan, S.P.Y. Li, J.K.W. Lam, C.K. Tsang, S.F. Chow*. “Mediating bio- fate of polymeric cholecalciferol nanoparticles through rational size control”, Biomater. Adv. (2022), 140, 213074.
S.N. Wong, J. Weng, I. Ip, R. Chen, R. Lakerveld, R. Telford, N. Blagden, I.J. Scowen, S.F. Chow*. “Rational development of a carrier-free dry powder inhalation formulation for respiratory viral infections via quality by design: a drug-drug cocrystal of favipiravir and theophylline”, Pharmaceutics (2022), 14 (2), 300.
S.N. Wong, K. Low, J. Weng, H.W. Chan, S.F. Chow*. “Expanding the solid-state landscape of dexamethasone: a specific sandwich structure in facilitating the formation of kinetically stable cocrystals from mechanochemistry”, CrystEngComm (2022), 24 (33), 5875-5879.
M.X. Li, J. Weng, E.S. Ho*, S.F. Chow*, C.K. Tsang* “Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury”, Neural Regen. Res. (2022), 17 (10), 2157. (An invited review)

2021

B. Xuan, Y.C.S. Chen, K.C. Wong, R. Chen, P.S. Lo, R. Lakerveld, H.H.Y. Tong, S.F. Chow*. “Impact of cocrystal solution-state stability on cocrystal dissociation and polymorphic drug recrystallization during dissolution”, Int. J. Pharm. (2021), 610, 121239.
X. Zhang, L.Y. Chau, H.W. Chan, J. Weng, K.W. Wong, S.F. Chow*, A.H.L. Chow*. “Physical stability and in vivo brain delivery of polymeric ibuprofen nanoparticles fabricated by flash nanoprecipitation", Int. J. Pharm. (2021), 598, 120224.
S.N. Wong, Y.C.S. Chen, B. Xuan, C.C. Sun, S.F. Chow*. “Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges”, CrystEngComm (2021),23, 7005- 7048. (An invited review)
X. Xie, M. Li, M. Zhou, S.F. Chow, C.K. Tsang* “Pharmacological preconditioning by TERT inhibitor BIBR1532 confers neuronal ischemic tolerance through TERT-mediated transcriptional reprogramming”, J. Neurochem. (2021), 159 (4), 690-709.
D. Guan, B. Xuan, C. Wang, R. Long, Y. Jiang, L. Mao, J. Kang, Z. Wang, S.F. Chow*, Q. Zhou*. “Improving the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients derived from traditional Chinese medicine through cocrystal engineering” Pharmaceutics (2021), 13 (12), 2160. (An invited review)

2020

J. Weng, H.H.Y. Tong, S.F. Chow*. “In vitro release study of the polymeric drug nanoparticles: development and validation of a novel method”, Pharmaceutics (2020) 12 (8), 732.
B. Xuan, S.N. Wong, Y. Zhang, J. Weng, H.H.Y. Tong, C. Wang, C.C. Sun, S.F. Chow*. “Extended release of highly water soluble isoniazid attained through cocrystallization with curcumin” Cryst. Growth Des. (2020), 20 (3), 1951-1960.
K.Y. Wan, J. Weng, S.N. Wong, P.C.L. Kwok, S.F. Chow*, A.H.L. Chow*. “Converting nanosuspension into inhalable and redispersible nanoparticles by combined in-situ thermal gelation and spray drying”, Eur. J. Pharm. Biopharm. (2020), 149, 238- 247.
S.N. Wong, S.W.S. Chan, X. Peng, B. Xuan, H.W. Lee, H.H.Y. Tong, S.F. Chow*. “Effects of the glass-forming ability and annealing conditions on cocrystallization behaviors via rapid solvent removal: A case study of voriconazole” Pharmaceutics (2020), 12 (12), 1209.
Q. Li, J. Weng, S.N. Wong, W.Y.T. Lee, S.F. Chow*. “Nanoparticulate drug delivery to the retina”, Mol. Pharm. (2020), 18(2), 506-521. (An invited review)
R. Chen, J. Weng, S.F. Chow, R. Lakerveld*. “Integrated continuous crystallization and spray drying of insulin for pulmonary drug delivery” Cryst. Growth Des. (2020), 21(1), 501-511.

2019

K.Y. Wan, S.N. Wong, K.W. Wong, S.F. Chow*, A.H.L. Chow*. “Interplay between amphiphilic stabilizers and cholesterol in the stabilization of itraconazole nanoparticles prepared by flash nanoprecipitation”, Mol. Pharm. (2019), 16, 195-204.
L.P. Sze, H.Y. Li, K.L.A. Lai, S.F. Chow, Q. Li, K.W.K. To, T.N.T. Lam, W.Y.T. Lee*. “Oral delivery of paclitaxel by polymeric micelles: A comparison of different block length on uptake, permeability and oral bioavailability”, Colloids and Surface B: Biointerfaces (2019), 184, 110554.
G.D. Hadiwinoto, P.C.L. Kwok, H.H.Y. Tong, S.N. Wong, S.F. Chow, R. Lakerveld*. “Integrated continuous plug-flow crystallization and spray drying of pharmaceuticals for dry powder inhalation”, Ind. Eng. Chem. Res. (2019), 58 (36), 16843-16857.
M.Y.T. Chow, Y. Qiu, P.C.L Kwok, S.F. Chow, H.K. Chan, J.K.W. Lam*. “High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin”, Int. J. Pharm. (2019), 572, 118818.
J. Tao, S.F. Chow, Y. Zheng*. “Application of flash nanoprecipitation to fabricate poorly water- soluble drug nanoparticles”, Acta Pharm. Sin. B. (2019), 9, 4-18.(An invited review)
Q. Liao, L. Yip, M.Y.T. Chow, S.F. Chow, H.K. Chan, P.C.L. Kwok, J.K.W. Lam*. “Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition”, Int. J. Pharm. (2019), 560, 144- 154.
S.F. Chow*, J. Weng, B. Xuan, K.Y. Wan. “How can the challenges faced by nanoparticle-based pulmonary drug formulation be overcome”, Ther. Deliv. (2019), 10 (2), 87-89. (An invited editorial)

2018

S.N. Wong, S. Hu, X. Xu, K.L Lai, W.Y.T. Lee, A.H.L. Chow, C.C. Sun*, S.F. Chow*. “Cocrystallization of curcumin with benzenediols and benzenetriols via rapid solvent removal” Cryst. Growth Des. (2018), 18(9), 5534-5546.
K.Y. Wan, K.W. Wong, A.H.L. Chow, S.F. Chow*. “Impact of molecular rearrangement of amphiphilic stabilizers on physical stability of itraconazole nanoparticles prepared by flash nanoprecipitation”, Int. J. Pharm. (2018), 542(1-2), 221-231.
W. Liang, M.Y.T. Chow, S.F. Chow, H.K. Chan, P.C.L. Kwok, J.K.W. Lam*. “Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation”, Int. J. Pharm. (2018), 552(1-2), 67-75.

BEFORE 2018

Y. Wang, J. Song, S.F. Chow, A.H.L. Chow, Y. Zheng. “Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution”, Nanomedicine: Nanotechnology, Biology and Medicine (2017), 13(3), 943-953.
S.F. Chow, K.Y. Wan, K.K. Cheng, K.W. Wong, C.C. Sun, L. Baum, A.H.L. Chow. “Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization”, Eur. J. Pharm. Biopharm. (2015), 94, 436-449.
Y. Wang, J. Song, S.F. Chow, A.H.L. Chow, Y. Zheng. “Particle size tailoring of ursolic acid nanosuspensions for improved anticancer activity by controlled antisolvent precipitation”, Int. J. Pharm. (2015), 494(1), 479-489.
S.F. Chow, C.C. Sun, A.H.L. Chow. “Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production”, Eur. J. Pharm. Biopharm. (2014), 88 (2) 462-471.
S.F. Chow, L. Shi, W.W. Ng, K.H.Y. Leung, K. Nagapudi, C.C. Sun, A.H.L. Chow. “Kinetic entrapment of a hidden curcumin cocrystal with phloroglucinol”, Cryst. Growth Des. (2014), 14(10), 5079-5089.
T.W. Lee, N.A. Boersen, H.W. Hui, S.F. Chow, K.Y. Wan, A.H.L. Chow. “Delivery of poorly soluble compounds by amorphous solid dispersions”, Curr. Pharm. Des. (2014), 20 (3), 303-324. (An invited review)
K.K. Cheng, C.F. Yeung, S.W. Ho, S.F. Chow, A.H.L. Chow, L. Baum. “Highly stabilized curcumin nanoparticles tested in an in vitro blood brain barrier model and in Alzheimer’s disease Tg2576 mice”, The AAPS Journal (2013), 15(2), 324-336.
S.F. Chow, M. Chen, L. Shi, A.H.L. Chow, C.C Sun. “Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide”, Pharm. Res. (2012), 29(7), 1854-1865.
H.H.Y. Tong, S.F. Chow, H.M. Chan, A.H.L. Chow, Y.K.Y. Wan, I.D. Williams, F.L.Y. Shek, C.K. Chan. “Process-induced phase transformation of berberine chloride hydrates”, J. Pharm. Sci. (2010), 99(4), 1942-1954.